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KMID : 0363220100480070611
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Korean Journal of Dermatology
2010 Volume.48 No. 7 p.611 ~ p.615
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Three Cases of Noninvoluting Congenital Hemangioma
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Lim Hyun-Jung
Jun Jae-Hun
Lee Weon-Ju
Lee Seok-Jong
Kim Do-Won
Chung Ho-Yun
Lee Jong-Min
Yun Kil-Suk
Jung Han-Jin
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Abstract
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Congenital hemangioma (CH), which is already fully formed at birth, is a rare clinical entity that is distinctly different from the common postnatally-occurring hemangioma of infancy (HOI). These two forms of CH have been described according to their clinical courses: apart from the clinical features of presentation at birth, there is the rapidly involuting congenital hemangioma (RICH) with rapid involution shortly after birth and the noninvoluting congenital hemangioma (NICH) with neither postnatal enlargement nor spontaneous involution. It is important to recognize this uncommon disease entity NICH in the early period because it has no tendency for spontaneous regression, so timely therapeutic intervention is needed, which is in contrast to that of HOI. We present 3 patients who were 1-, 3- and 13-year-old girls with red-stippled blue to blue gray vascular lesion. They all showed their lesions since birth and the lesions remained unchanged with no subjective symptoms. Doppler ultrasonography demonstrated a well-defined fast-flowed vascular lesion confined to the dermis and subcutis. The histology commonly showed lobular growth of capillaries, centrilobular irregular and often stellate vessels, extralobular large vessels and more conclusively, negative staining for GLUT-1, which is unlike HOI.
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KEYWORD
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Congenital hemangioma, GLUT-1, Hemangioma, Noninvoluting congenital hemangioma
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